A One-pot Process for the Synthesis of Indole and Indole Derivatives

Non-Confidential description of the invention

The invention relates to a novel one-pot process for the preparation of indole and derivatives of indole via SN2 type ring opening of aziridine derivatives followed by metal catalyzed C-N cyclization and aromatization. More particularly, it relates to an one-pot process for the preparation of 2-alkyl indole via SN2 type ring opening of 2-(2-haloaryl)-N-activated aziridine derivatives followed by metal catalyzed C-N cyclization and aromatization. Object of the invention is to provide a novel one pot process for the preparation of halogenated 2-alkyl indole derivatives from N-activated aziridine derivatives, also to provide a commercially scalable preparation of indole derivatives in high yield. The process for the synthesis of Indole derivatives is cost-effective and environmentally.

Inventors

Prof.M.K.Ghorai(CHM),Masthanvali Sayyad(CHM),Yerramsetti Nanaji(CHM)

IPA

3880/DEL/2015

Date of Filing

27/11/2015

Status

Date Of Grant

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