Combination of Fluorenylmethyloxycarbonyl Conjugated Amino Acids (Fmoc-AA) and Membrane Permeabilizing Agents against Gram-negative Bacteria
Non-Confidential description of the invention
Provided herein is a combination for treating bacterial infections, comprising a Fmoc amino acid and a membrane permeabilizer. Particularly, the present invention provides a synergistic combination against Gram-negative bacteria comprising Fmoc-phenylalanine and Aztreonam. Also provided herein is a hydrogel for treating bacterial infections comprising Fmoc-amino acid, wherein a membrane permeabilizer is encapsulated in the hydrogel. Particularly, the present invention provides aztreonam encapsulated Fmocphenylalanine hydrogel for treating both Gram-positive and Gram-negative bacterial infections.
Mr. Avinash Yashwant Gahane (PhD Student, BSBE), Dr. Ashwani Kumar Thakur (BSBE)
Date of Filing