Peptide Encapsulated Biodegradable Nanoparticles for Treatment of Neurodegenerative Diseases and Preparation Method Thereof
Non-Confidential description of the invention
The invention is related to the design, synthesis and development of biodegradable nanoparticles containing peptide inhibitors of polyglutamine aggregation that can be used as a treatment modality against Huntington’s disease and other polyglutamine expansion related diseases. Polyglutamine aggregation is believed to be a fundamental problem of Huntington’s disease (HD) and eight other neurodegenerative diseases. Many mechanism based peptide molecules have been developed that inhibit polyglutamine aggregation, but their penetration across BBB has not been confirmed. Moreover, they may undergo degradation in vivo by several enzymes. Hence, using a nanoparticulate delivery system, these peptides can be delivered to the brain, where their therapeutic potential can be tested against polyglutamine aggregation.
Dr. Aswani Kumar Thakur (BSBE), Mr. Abhayraj S. Joshi (PhD Student, BSBE)
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