Polydimethylsiloxane(PDMS) Nanoparticles and Process of Synthesizing the Same for Ligand Free Intra-Nuclear Delivery of Drugs

Non-Confidential description of the invention

The present invention relates to a process of synthesizing polydimethylsiloxane (PDMS) nanoparticles for ligand free intra-nuclear delivery of drugs. The method comprises preparing solid core-mesoporous shell (SCMS) silica particles. Further, the SCMS silica particles are added to a solution of PDMS to form a mixture. The mixture is centrifuged for a predetermined time. The mixture is incubated for atleast 16 hours. The mixture is cured at a predetermined temperature of 100°C and a predetermined time of 9 hours. The mixture is etched with ammonium fluoride buffered HF solution and washed to obtain PDMS nanoparticles.


Dr. Ashutosh Sharma (ChE), Dr. Sri Sivakumar (ChE), Mrs. Gargi Mishra (PhD Student),Mr.Souryadeep Bhattacharyya (Student),



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